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Smertestillende præparater med det aktive stof acetylsalicylsyre anbefales slet ikke af Sundhedsstyrelsen.De syntetiske opioider petidin og fentanyl virker på de samme modtagere i nervesystemet som morfin, og de ligner morfin i deres virkning og bivirkninger. Midlerne er vist i tabel two.Der er forskellige holdninger til smertestillende medicin.